Adipothera™

Engineering the Stromal Response

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Beyond Symptoms, Toward Solutions.

For intractable diseases driven by fibrosis and inflammation, we look deeper. Our platform deciphers the complex language of the stromal microenvironment to develop therapies that don't just manage damage—they command repair.

Explore Our Programs
Explore Our Programs
Beyond Symptoms, Toward Solutions.

Our platform deciphers the complex stromal microenvironment.

"We program the stromal response. By letting AI perceive what biology hides, we unlock first-in-class therapies for conditions once considered unsolvable."
Shailesh Agarwal MD
Founder of Adipothera™

About us

We design programs that redirect stromal biology toward durable repair.

Leveraging computation and multi-modal datasets, our pipeline generates first-in-class drug candidates that are computationally guided, assay-proven, and clinically motivated.

More about us
More about us

Breakthrough Programs

1

Radiation Injury

Chronic inflammation & fibrosis
Stromal reprogramming
Depiction of radiation effects on tissue.

Our lead candidate, AT-001, is designed to attenuate inflammatory cascades while supporting structural recovery—shifting outcomes away from fibrosis and towards repair.

2

Lymphedema

Impaired lymphatic function
Restoring microenvironmental homeostasis
Representation of lymphatic swelling.

Our topical program, featuring AT-001, aims to reduce chronic swelling and prevent maladaptive tissue remodeling by tuning stromal-immune interactions.

3

Fibrodysplasia Ossificans Progressiva (FOP) / Heterotopic Ossification (HO)

Aberrant osteogenesis
Modulating pro-osteogenic signaling
Illustration of bone formation in soft tissues.

Our oral candidate, AT-002, demonstrates selective interference with pro-osteogenic signaling by modulating stromal cues that initiate aberrant bone formation.

Get in touch
Get in touch

Pipeline

Candidates

AT-001 (Topical)

  • Local delivery to stromal targets

  • Designed for radiation injury and lymphedema flares

  • Computationally guided protein–ligand selectivity

  • Optimized for barrier penetration and residence time

  • Preclinical readouts on repair vs. scarring

Localized, durable effect
Translatable topical profile

AT-002 (Oral)

  • Systemic control of aberrant stromal activation

  • FOP/HO focus with flare mitigation strategy

  • In-silico triage to bias potency and safety

  • PK/PD modeling aligned to clinical endpoints

  • Manufacturability and oral bioavailability screens

Systemic, precise
Oral first-in-class profile

Each program originates from the same engine: AI-driven discovery grounded in biophysics and validated in disease-relevant assays.