Adipothera®
Engineering the Stromal Response
Programmable stromal biology for optimal repair.
"From computation to clinic, we program the stromal response. By letting AI perceive what biology hides, we unlock first-in-class therapies for conditions once considered unsolvable."
About us
We build small-molecule programs that redirect stromal biology toward durable repair.
Our platform fuses multimodal datasets with physics-informed models to map actionable targets in fibrotic and inflammatory microenvironments. The result: drug candidates that are computationally guided, assay-proven, and clinically motivated.
Breakthrough Programs
Fibrodysplasia Ossificans Progressiva (FOP) / Heterotopic Ossification (HO)
We modulate stromal cues that initiate aberrant bone formation. Candidates emerging from our in-silico pipeline demonstrate selective interference with pro-osteogenic signaling while preserving homeostatic repair.
Lymphedema
By tuning stromal-immune interactions and lymphatic tone, our candidates aim to reduce chronic swelling and prevent maladaptive tissue remodeling.
Radiation Injury
Our chemistry is designed to attenuate inflammatory cascades while supporting structural recovery—shifting outcomes away from fibrosis and towards repair.
Pipeline
Candidates
AT-001 (Topical)
Local delivery to stromal targets
Designed for radiation injury and lymphedema flares
Computationally guided protein–ligand selectivity
Optimized for barrier penetration and residence time
Preclinical readouts on repair vs. scarring
AT-002 (Oral)
Systemic control of aberrant stromal activation
FOP/HO focus with flare mitigation strategy
In-silico triage to bias potency and safety
PK/PD modeling aligned to clinical endpoints
Manufacturability and oral bioavailability screens
Each program originates from the same engine: AI-driven discovery grounded in biophysics and validated in disease-relevant assays.